Article
Lineage commitment in lymphopoiesis.
Current opinion in immunology - 1 Apr 2000
Busslinger M, Nutt S L, Rolink A G
Abstract excerpt
The mechanisms controlling the commitment of hematopoietic progenitor cells to the lymphoid lineages are still mostly unknown. Recent findings indicate that the earliest phase of B cell development may proceed in two steps. At the onset of B-lymphopoiesis, the transcription factors E2A and EBF coordinately activate the B-cell-specific gene expression program. Subsequently, Pax5 appears to repress the promiscuous...
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