Article
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Feb 2001
Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K
Abstract excerpt
Notch signaling plays an important role in cell-fate specification in multicellular organisms by regulating cell-cell communication. The Drosophila deltex gene encodes a modulator of the Notch pathway that has been shown to interact physically with the Ankyrin repeats of Notch. We isolated four distinct cDNAs corresponding to mouse homologs of deltex - mouse Deltex1 (MDTX1), mouse Deltex2 (MDTX2), mouse...
Topics
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Cell Differentiation
- Cell Lineage
- Cells, Cultured
- DNA, Complementary
- Drosophila Proteins
- Drosophila melanogaster