Article
Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Nature immunology - 1 May 2002
Gounari Fotini, Aifantis Iannis, Martin Colin, Fehling Hans-Joerg, Hoeflinger Sonja, Leder Philip, von Boehmer Harald, Reizis Boris
Abstract excerpt
A transgenic reporter mouse strain, which expressed the human CD25 (hCD25) surface marker as a reporter under the control of the pre-T cell receptor alpha(pTalpha) promoter, was used to identify lymphoid precursors that expressed pTalpha intracellularly. The hCD25 reporter marked intra- and extrathymic precursors of lymphocytes but not myeloid cells. The earliest intrathymic precursors were...
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