Article
Analysis of immune regulatory genes in familial and sporadic Graves' disease.
The Journal of clinical endocrinology and metabolism - 1 Sept 2004
Ban Yoshiyuki, Concepcion Erlinda S, Villanueva Ronald, Greenberg David A, Davies Terry F, Tomer Yaron
Abstract excerpt
Graves' disease (GD) is seen in apparently sporadic and familial forms. At least two immune regulatory genes are associated with GD, human leukocyte antigen (HLA) and cytotoxic T lymphocyte antigen-4 (CTLA-4). The aim of our study was to examine the contributions of HLA and CTLA-4 to the familial clustering of GD by analyzing them for association with familial and sporadic GD. We analyzed 160 Caucasian GD...
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