Article
Genetic study of early-onset Graves' disease in the Chinese Han population.
Clinical genetics - 1 Jan 2018
Yuan F-F, Ye X-P, Liu W, Xue L-Q, Ma Y-R, Zhang L-L, Zhang M-M, Sun F, Wan Y-Y, Zhang Q-Y, Zhao S-X, Song H-D
Abstract excerpt
Graves' disease (GD) is a complex autoimmune disorder in which genetic and environmental factors are both involved in the pathogenesis. Early-onset patients have a shorter exposure time to environmental factors and are, therefore, good models to help understand the genetic architecture of GD. Based on previous studies of early-onset GD, 11 single nucleotide polymorphisms (SNPs) and their related SNPs (R2 > .6),...
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