Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differences in Gene-Gene Interactions in Graves' Disease Patients Stratified by Age of Onset.

PloS one - 1 Jan 2016

Jurecka-Lubieniecka Beata, Bednarczuk Tomasz, Ploski Rafal, Krajewska Jolanta, Kula Dorota, Kowalska Malgorzata, Tukiendorf Andrzej, Kolosza Zofia, Jarzab Barbara

Abstract excerpt

BACKGROUND: Graves' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. Each gene exerts limited effects on the development of autoimmune disease (OR = 1.2-1.5). An epidemiological study revealed that nearly 70% of the risk of developing inherited autoimmunological thyroid diseases (AITD) is the result of gene interactions. In the present study, we analyzed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Frequency

Share to Graves Disease

Share to Multifactor Dimensionality Reduction

Share to Odds Ratio

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 26943356
DOI: 10.1371/journal.pone.0150307
PMCID: PMC4778933

Genes

PTPN22
CTLA4
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differences in Gene-Gene Interactions in Graves' Disease Patients Stratified by Age of Onset.PMID 26943356Read ↗

The genetics of Graves' disease.Semantic proximity Read ↗

Role of genetic and non-genetic factors in the etiology of Graves' disease.Semantic proximity Read ↗

Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease.Semantic proximity Read ↗

Graves' disease: introducing new genetic and epigenetic contributors.Semantic proximity Read ↗

Genotype-phenotype correlations in Graves' disease.Semantic proximity Read ↗

The genetics of Graves' disease.Semantic proximity Read ↗

Association between age at diagnosis of Graves' disease and variants in genes involved in immune response.Semantic proximity Read ↗

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.Semantic proximity Read ↗

Outcome of Graves’ Disease and Associated Genetic Predisposition: A Systematic Review of LiteratureSemantic proximity Read ↗

ITM2A Expands Evidence for Genetic and Environmental Interaction in Graves Disease Pathogenesis.Semantic proximity Read ↗

Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.Semantic proximity Read ↗

Genetic analysis in young-age-of-onset Graves' disease reveals new susceptibility loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.