Article
Influence of LRP5 polymorphisms on normal variation in BMD.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2004
Koay M Audrey, Woon Peng Y, Zhang Yun, Miles Lisa J, Duncan Emma L, Ralston Stuart H, Compston Juliet E, Cooper Cyrus, Keen Richard, Langdahl Bente L, MacLelland Alasdair, O'Riordan Jeffrey, Pols Huibert A, Reid David M, Uitterlinden Andre G, Wass John A H, Brown Matthew A
Abstract excerpt
UNLABELLED: Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900...
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