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Common Genetic Variation of the <i>Low-Density Lipoprotein Receptor-Related Protein 5</i> and <i>6</i> Genes Determines Fracture Risk in Elderly White Men

1 Jan 2006

Abstract excerpt

UNLABELLED: Both LRP5 and LRP6 genes have been implicated to play a role in bone metabolism. In a large population-based study, we related common variation in both genes to bone parameters and fractures. LRP5 variation was associated to both BMD and frame size, whereas both LRP5 and 6 variations were associated with an increased fracture risk in males. INTRODUCTION: The low-density lipoprotein receptor-related...

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PMID: 16355283
DOI: 10.1359/jbmr.050904

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