Article
LRP5 gene polymorphisms and idiopathic osteoporosis in men.
Bone - 1 Dec 2005
Ferrari S L, Deutsch S, Baudoin C, Cohen-Solal M, Ostertag A, Antonarakis S E, Rizzoli R, de Vernejoul M C
Abstract excerpt
Mutations in the low-density lipoprotein receptor-related protein 5 gene (LRP5) have demonstrated the role of LRP5 in bone mass acquisition. LRP5 variants were recently reported to contribute to the population-based variance in vertebral bone mass and size in males. To investigate whether LRP5 variants are implicated in idiopathic male osteoporosis, we studied 78 men with low BMD (<2.5 T score or < -2 Z score)...
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