Article
Contribution of the LRP5 gene to normal variation in peak BMD in women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2005
Koller Daniel L, Ichikawa Shoji, Johnson Michelle L, Lai Dongbing, Xuei Xiaoling, Edenberg Howard J, Conneally P Michael, Hui Siu L, Johnston C Conrad, Peacock Munro, Foroud Tatiana, Econs Michael J
Abstract excerpt
UNLABELLED: The role of the LRP5 gene in rare BMD-related traits has recently been shown. We tested whether variation in this gene might play a role in normal variation in peak BMD. Association between SNPs in LRP5 and hip and spine BMD was measured in 1301 premenopausal women. Only a small proportion of the BMD variation was attributable to LRP5 in our sample. INTRODUCTION: Mutations in the low-density...
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