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Article

A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2008

Agueda Lídia, Bustamante Mariona, Jurado Susana, Garcia-Giralt Natalia, Ciria Manel, Saló Guillem, Carreras Ramon, Nogués Xavier, Mellibovsky Leonardo, Díez-Pérez Adolfo, Grinberg Daniel, Balcells Susana

Abstract excerpt

LRP5 encodes the low-density lipoprotein receptor-related protein 5, a transmembrane protein involved in Wnt signaling. LRP5 is an important regulator of osteoblast growth and differentiation, affecting bone mass in vertebrates. Whether common variations in LRP5 are associated with normal BMD variation or osteoporotic phenotypes is of great relevance. We used a haplotype-based approach to search for common...

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Source

Identifiers

PMID: 18684085
DOI: 10.1359/jbmr.080806

Genes

LRP5
RUNX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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