Article
Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men.
Bone - 1 Mar 2007
Kiel Douglas P, Ferrari Serge L, Cupples L Adrienne, Karasik David, Manen Danielle, Imamovic Alma, Herbert Alan G, Dupuis Josée
Abstract excerpt
Polymorphisms in the LRP5 gene have been associated with bone mineral density (BMD) in men and/or women. However, the functional basis for this association remains obscure. We hypothesized that LRP5 alleles could modulate Wnt signaling and the relationship between physical activity and BMD. This genetic association study was performed in the population-based Framingham Study Offspring Cohort, and included a...
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