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Article

The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes.

Endocrinology - 1 Jun 2007

Balemans Wendy, Van Hul Wim

Abstract excerpt

A few years ago, human genetic studies provided compelling evidence that the low-density lipoprotein receptor-related protein 5 (LRP5) is involved in the regulation of bone homeostasis because pathogenic LRP5 mutations were found in monogenic conditions with abnormal bone density. On the one hand, the osteoporosis pseudoglioma syndrome results from loss of function of LRP5, whereas on the other hand,...

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Source

Identifiers

PMID: 17395706
DOI: 10.1210/en.2006-1352

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes.PMID 17395706Read ↗

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