Article

Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysis

2026-07-27

Abstract excerpt

Abstract Background The low-density lipoprotein receptor-related protein 5 ( LRP5 ) gene is a key regulator of bone mineral density and skeletal metabolism. The rs3736228 (Ala1330Val) polymorphism in LRP5 has been firmly established as a genome-wide significant locus for bone mineral density and fracture risk in large-scale GWAS. However, demographic and clinical subgroups that are frequently underrepresented in G...

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Literature Corpus work: 05bd8a63-81c1-5a97-80f4-4b94c9f4ad2b
DOI: 10.1186/s12891-026-10270-9

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