Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysis.

doi:10.1186/s12891-026-10270-9

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Article

Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysis.

BMC musculoskeletal disorders - 27 Jul 2026

Zhang Chi, Liu Wuhua, Wang Youhua, Peng Yuyi

Abstract excerpt

BACKGROUND: The low-density lipoprotein receptor-related protein 5 (LRP5) gene is a key regulator of bone mineral density and skeletal metabolism. The rs3736228 (Ala1330Val) polymorphism in LRP5 has been firmly established as a genome-wide significant locus for bone mineral density and fracture risk in large-scale GWAS. However, demographic and clinical subgroups that are frequently underrepresented in GWAS...

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Topics

Humans
Low Density Lipoprotein Receptor-Related Protein-5
Osteoporosis
Genetic Predisposition to Disease
Fractures, Bone
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Bone Density

Female

Genome-Wide Association Study

Risk Factors

Osteoporotic Fractures

Source

Open in PubMed Open full text

Identifiers

PMID: 42907799
DOI: 10.1186/s12891-026-10270-9
PMCID: PMC13689123

Genes

LRP5

Variants

rs3736228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 28 Oct 2026.