Article
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.
JAMA - 19 Mar 2008
van Meurs Joyce B J, Trikalinos Thomas A, Ralston Stuart H, Balcells Susana, Brandi Maria Luisa, Brixen Kim, Kiel Douglas P, Langdahl Bente L, Lips Paul, Ljunggren Osten, Lorenc Roman, Obermayer-Pietsch Barbara, Ohlsson Claes, Pettersson Ulrika, Reid David M, Rousseau Francois, Scollen Serena, Van Hul Wim, Agueda Lidia, Akesson Kristina, Benevolenskaya Lidia I, Ferrari Serge L, Hallmans Göran, Hofman Albert, Husted Lise Bjerre, Kruk Marcin, Kaptoge Stephen, Karasik David, Karlsson Magnus K, Lorentzon Mattias, Masi Laura, McGuigan Fiona E A, Mellström Dan, Mosekilde Leif, Nogues Xavier, Pols Huibert A P, Reeve Jonathan, Renner Wilfried, Rivadeneira Fernando, van Schoor Natasja M, Weber Kurt, Ioannidis John P A, Uitterlinden André G
Abstract excerpt
CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population. OBJECTIVE: To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and...
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