Article
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.
Molecular biology of the cell - 1 May 1992
Mason J O, Kitajewski J, Varmus H E
Abstract excerpt
The proto-oncogene Wnt-1 encodes a cysteine-rich, secretory glycoprotein implicated in virus-induced mouse mammary cancer and intercellular signaling during vertebrate neural development. To attempt to correlate structural motifs of Wnt-1 protein with its function, 12 mutations were introduced si...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Cysteine
- DNA Mutational Analysis
- Glycosylation
- Hot Temperature
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Proto-Oncogene Proteins
- Transformation, Genetic
- Wnt Proteins
- Wnt1 Protein
- Zebrafish Proteins