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Article

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.

Molecular biology of the cell - 1 May 1992

Mason J O, Kitajewski J, Varmus H E

Abstract excerpt

The proto-oncogene Wnt-1 encodes a cysteine-rich, secretory glycoprotein implicated in virus-induced mouse mammary cancer and intercellular signaling during vertebrate neural development. To attempt to correlate structural motifs of Wnt-1 protein with its function, 12 mutations were introduced singly and in several combinations into the coding sequence of Wnt-1 cDNA by site-directed mutagenesis. Mutant alleles in...

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Identifiers

PMID: 1535241
DOI: 10.1091/mbc.3.5.521
PMCID: PMC275605

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Source receipt: pubmed, retrieved 7 Sept 2026.

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