Article
Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.
Journal of virology - 1 Sept 1990
Engelman A, Rosenberg N
Abstract excerpt
The effect of two missense mutations in abl on transformation by Abelson murine leukemia virus was evaluated. These mutations led to the substitution of a histidine for Tyr-590 and a glycine for Lys-536. Both changes gave rise to strains that were temperature dependent for transformation of both...
Topics
- Abelson murine leukemia virus
- Amino Acid Sequence
- Amino Acids
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Kinetics
- Leukemia Virus, Murine
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Phosphotyrosine
- Plasmids
- Protein-Tyrosine Kinases
- Temperature
- Tyrosine