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Article

Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice.

Molecular and cellular biology - 1 Jun 2000

Hoemann C D, Beaulieu N, Girard L, Rebai N, Jolicoeur P

Abstract excerpt

We have previously characterized a large panel of provirus insertion Notch1 mutant alleles and their products arising in thymomas of MMTV(D)/myc transgenic mice. Here, we show that these Notch1 mutations represent two clearly distinct classes. In the first class (type I), proviral integrations were clustered just upstream of sequences encoding the transmembrane domain. Type I Notch1 alleles produced two types of...

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Share to Leukemia, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 10805726
DOI: 10.1128/MCB.20.11.3831-3842.2000
PMCID: PMC85710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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