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Article

All three domains of the Epstein-Barr virus-encoded latent membrane protein LMP-1 are required for transformation of rat-1 fibroblasts.

Journal of virology - 1 Mar 1993

Moorthy R K, Thorley-Lawson D A

Abstract excerpt

LMP-1, the Epstein-Barr virus latent membrane protein 1, is the only protein encoded by the virus that has been shown to have the properties of a transforming oncogene in rodent fibroblasts such as Rat-1 cells. LMP-1 is phosphorylated and proteolytically cleaved in Rat-1 cells in a manner similar to that seen in human lymphocytes. In this study, we demonstrate that all three major domains of LMP-1 (N-terminal,...

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Identifiers

PMID: 8382313
DOI: 10.1128/JVI.67.3.1638-1646.1993
PMCID: PMC237535

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