Article
Generation of a temperature-sensitive cSRC.
Virology - 1 Sept 1993
Koegl M, Goldberg Y, Courtneidge S A
Abstract excerpt
We have created retroviruses encoding a temperature-sensitive variant of the cSrc protein, and of its activated allele cSrc(Y527F). Cells expressing the activated allele harboring this mutation displayed a transformed phenotype when grown at 34 degrees, but not at 39 degrees, as quantitated by me...
Topics
- Alleles
- Animals
- Cells, Cultured
- Electrophoresis, Polyacrylamide Gel
- Mutation
- Proto-Oncogene Proteins pp60(c-src)
- Rats
- Retroviridae
- Temperature