Article
Impairment of mammary lobular development induced by expression of TGFbeta1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice.
International journal of cancer - 15 May 2001
Buggiano V, Schere-Levy C, Abe K, Vanzulli S, Piazzon I, Smith G H, Kordon E C
Abstract excerpt
It has previously been shown that transgenic female mice expressing TGFbeta1 under control of regulatory elements of the whey-acidic protein (WAP) gene were unable to lactate. This was due to the increased apoptosis of the cells committed to the lobular-lactogenic phenotype. Our goal was to determine whether the expression of WAP-TGFbeta1 transgene could inhibit MMTV (mouse mammary tumor virus) tumorigenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.