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Article

The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation.

Transplant international : official journal of the European Society for Organ Transplantation - 1 Oct 2004

Fabre Margarete A, Jones Des C, Bunce Mike, Morris Peter J, Friend Peter J, Welsh Ken I, Marshall Sara E

Abstract excerpt

Azathioprine metabolism is influenced by activity of the enzyme thiopurine S-methyltransferase (TPMT), which varies markedly between individuals. In this study we examined the influence of TPMT gene polymorphisms on azathioprine dose 1 year after renal transplantation. TPMT coding and promoter genotypes were determined using PCR-based assays. Azathioprine dose, white cell count, and intercurrent events throughout...

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Share to Azathioprine
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Leukopenia

Share to Methyltransferases

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 15349717
DOI: 10.1007/s00147-004-0737-0

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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