Article
The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation.
Transplant international : official journal of the European Society for Organ Transplantation - 1 Oct 2004
Fabre Margarete A, Jones Des C, Bunce Mike, Morris Peter J, Friend Peter J, Welsh Ken I, Marshall Sara E
Abstract excerpt
Azathioprine metabolism is influenced by activity of the enzyme thiopurine S-methyltransferase (TPMT), which varies markedly between individuals. In this study we examined the influence of TPMT gene polymorphisms on azathioprine dose 1 year after renal transplantation. TPMT coding and promoter genotypes were determined using PCR-based assays. Azathioprine dose, white cell count, and intercurrent events throughout...
Topics
- Azathioprine
- Dose-Response Relationship, Drug
- Gene Frequency
- Genotype
- Humans
- Immunosuppressive Agents
- Kidney Transplantation
- Leukopenia
- Methyltransferases
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Retrospective Studies