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Article

The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.

Therapeutic drug monitoring - 1 Aug 2005

Kurzawski Mateusz, Dziewanowski Krzysztof, Gawrońska-Szklarz Barbara, Domański Leszek, Droździk Marek

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine. TPMT activity exhibits an interindividual variability, mainly as a result of genetic polymorphism. Patients with intermediate or deficient TMPT activity are at risk for toxicity after receiving standard doses of thiopurine drugs. It has previously been...

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Source

Identifiers

PMID: 16044099
DOI: 10.1097/01.ftd.0000164393.09402.c9

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.PMID 16044099Read ↗

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Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

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Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine-induced myelosuppression in heart transplant recipients.Semantic proximity Read ↗

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