Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of the heterozygous TPMT1/3C genotype on azathioprine-induced myelosuppression in kidney transplant recipients in Thailand.

Clinical therapeutics - 1 Jul 2009

Vannaprasaht Suda, Angsuthum Susothorn, Avihingsanon Yingyos, Sirivongs Dhavee, Pongskul Cholatip, Makarawate Pattarapong, Praditpornsilpa Kearkiat, Tassaneeyakul Wongwiwat, Tassaneeyakul Wichittra

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a polymorphic enzyme associated with detoxification of azathioprine, an immunosuppressant used after renal transplantation in several Asian countries. Patients with variations of the TPMT gene may be at risk for myelosuppression after they receive a standard dosage of the drug. The frequency of TPMT*3C has been reported to be higher in the Thai population than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Azathioprine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematologic Diseases

Share to Heterozygote

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Methyltransferases

Share to Thailand

Source

Identifiers

PMID: 19695401
DOI: 10.1016/j.clinthera.2009.07.008

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of the heterozygous TPMT*1/*3C genotype on azathioprine-induced myelosuppression in kidney transplant recipients in Thailand.PMID 19695401Read ↗

TPMT genotype and its clinical implication in renal transplant recipients with azathioprine treatment.Semantic proximity Read ↗

The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.Semantic proximity Read ↗

Severe azathioprine-induced myelotoxicity in a kidney transplant patient with thiopurine S-methyltransferase-deficient genotype (TPMT*3A/*3C).Semantic proximity Read ↗

Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

Thiopurine S-methyltransferase polymorphism in Iranian kidney transplant recipients.Semantic proximity Read ↗

Thiopurine S-methyltransferase genetic polymorphism in the Thai population.Semantic proximity Read ↗

Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.Semantic proximity Read ↗

The frequency and distribution of thiopurine S-methyltransferase alleles in south Iranian population.Semantic proximity Read ↗

Frequency of thiopurine S-methyltransferase (TPMT) alleles in southeast Iranian population.Semantic proximity Read ↗

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.Semantic proximity Read ↗

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.