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Article

Thiopurine S-methyltransferase polymorphism in Iranian kidney transplant recipients.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Aug 2011

Aghdaie Mahdokht Hossein, Azarpira Negar, Geramizadeh Bita, Sagheb Mehdi, Darai Masumeh, Rahsaz Marjan, Malekhoseini Seid Ali

Abstract excerpt

OBJECTIVES: Thiopurine S-methyltransferase is an enzyme that catalyzes S-methylation of azathioprine as an immunosuppressive drug. Genetic polymorphisms influence thiopurine S-methyltransferase activity. There are 3 variant alleles: thiopurine S-methyltransferase*2, *3A, and *3C are responsible for more than 95% cases of low-enzyme activity. MATERIALS AND METHODS: We studied these polymorphisms and the occurrence...

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PMID: 21819368

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