Article
6-Mercaptopurine pharmacokinetics after use of azathioprine in renal transplant recipients with intermediate or high thiopurine methyl transferase activity phenotype.
The Journal of pharmacy and pharmacology - 1 Nov 1998
Escousse A, Guedon F, Mounie J, Rifle G, Mousson C, D'Athis P
Abstract excerpt
Prevention of allograft transplant rejection by the immunosuppressive 6-thiopurine drug azathioprine is limited by haematological toxicity (leucopenia or agranulocytosis). This toxicity is particularly apparent in subjects with low thiopurine methyltransferase activity (TPMTase) phenotype (1% in...
Topics
- Adolescent
- Adult
- Area Under Curve
- Azathioprine
- Calibration
- Child
- Chromatography, High Pressure Liquid
- Drug Interactions
- Female
- Half-Life
- Humans
- Kidney Transplantation
- Male
- Mercaptopurine
- Methyltransferases
- Middle Aged
- Phenotype
- Reproducibility of Results