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Article

Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype.

Nucleosides, nucleotides & nucleic acids - 1 Oct 2004

Arenas M, Duley J A, Ansari A, Shobowale-Bakre E A, Fairbanks L, Soon S Y, Sanderson J, Marinaki A M

Abstract excerpt

Thiopurine drug therapy has been reported to lead to a variable increase in red cell TPMT activity that may alter effective dose and therapeutic outcome. The aim of this study was to correlate Variable Number Tandem Repeat (VNTR) in the promoter region of the TPMT gene with induction of red cell TPMT activity in patients treated with azathioprine (AZA). In 58 patients, TPMT activity measured at 3 months was not...

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Source

Identifiers

PMID: 15571267
DOI: 10.1081/NCN-200027643

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype.PMID 15571267Read ↗

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