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Article

Importance of thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity.

Neuro endocrinology letters - 1 Jan 2009

Kolorz Michal, Bartosova Ladislava, Hosek Jan, Dvorackova Dana, Chylkova Alicja, Zboril Vladimir, Batovsky Marian, Bartos Milan

Abstract excerpt

OBJECTIVES: Our study aims to find the relationship between metabolic enzyme thiopurine S-methyltransferase (TPMT) gene polymorphisms and clinical output of the therapy with azathioprine. We focused on patients who experienced leucopenia caused by high blood levels of active azathioprine metabolites. DESIGN: Our group consists of 87 patients who have been treated by azathioprine. 21 individuals experienced...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20027160

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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