Article
The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.
Nucleosides, nucleotides & nucleic acids - 1 Oct 2004
Coulthard S A, Matheson E C, Hall A G, Hogarth L A
Abstract excerpt
Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although current treatment results in long term survival in over 70% of cases there is evidence that as many as 50% could have been cured using a less complex regimen with a lower incidence of long term side effects. In previous studies it has been found that thiopurines given as part of continuing therapy are key agents in preventing...
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