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Article

TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients.

European journal of clinical pharmacology - 1 May 2009

Kurzawski Mateusz, Dziewanowski Krzysztof, Lener Agnieszka, Drozdzik Marek

Abstract excerpt

PURPOSE: Thiopurine drugs have to be withdrawn in 10-30% of cases due to side effects, and it has been presented that genetic factors may be responsible for some of reported toxicity cases. Among polymorphic enzymes of thiopurines' metabolic pathway, thiopurine S-methyltransferase (TPMT) has been studied most extensively, and some recent studies point to inosine triphosphate pyrophosphohydrolase (ITPA)...

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Source

Identifiers

PMID: 19229528
DOI: 10.1007/s00228-009-0630-y

Genes

TPMT
ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients.PMID 19229528Read ↗

TPMT genotype and its clinical implication in renal transplant recipients with azathioprine treatment.Semantic proximity Read ↗

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).Semantic proximity Read ↗

TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.Semantic proximity Read ↗

Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis.Semantic proximity Read ↗

Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients.Semantic proximity Read ↗

Mutation in the ITPA gene predicts intolerance to azathioprine.Semantic proximity Read ↗

The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

ITPA Activity in Adults and Children Treated With or Without Azathioprine: Relationship Between TPMT Activity, Thiopurine Metabolites, and Co-medications.Semantic proximity Read ↗

Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance, and pancreatitis in azathioprine-treated patients.Semantic proximity Read ↗

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