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Article

Utility of assessing thiopurine S-methyltransferase polymorphisms before azathioprine therapy.

Current drug metabolism - 1 Nov 2012

Cabaleiro Teresa, Roman Manuel, Gisbert Javier P, Abad-Santos Francisco

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) catalyzes the methylation of thiopurine drugs, such as azathioprine and mercaptopurine, which are used in a variety of diseases. Several mutations in the TPMT gene correlate with low enzyme activity and subsequent adverse effects, mainly myelotoxicity. Hence, genotyping TPMT makes it possible to identify patients at high risk of drug toxicity and adjust dosage accordingly....

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Source

Identifiers

PMID: 22493988
DOI: 10.2174/138920012803341311

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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