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Article

Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor.

The Journal of biological chemistry - 19 Nov 2004

Namkung Yoon, Sibley David R

Abstract excerpt

Previously, D2 dopamine receptors (D2 DARs) have been shown to undergo G-protein-coupled receptor kinase phosphorylation in an agonist-specific fashion. We have now investigated the ability of the second messenger-activated protein kinases, protein kinase A (PKA) and protein kinase C (PKC), to mediate phosphorylation and desensitization of the D2 DAR. HEK293T cells were transiently transfected with the D2 DAR and...

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Identifiers

PMID: 15347675
DOI: 10.1074/jbc.M408319200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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