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Article

The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4.

Molecular pharmacology - 1 Mar 2006

Rankin Michele L, Marinec Paul S, Cabrera David M, Wang Zheng, Jose Pedro A, Sibley David R

Abstract excerpt

G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate agonist-activated GPCRs, initiating their homologous desensitization. In this article, we present data showing that GRK4 constitutively phosphorylates the D1 receptor in the absence of agonist activation. This constitutive phosphorylation is mediated exclusively by the alpha isoform of GRK4; the beta, gamma, and delta isoforms are ineffective in this...

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Source

Identifiers

PMID: 16338988
DOI: 10.1124/mol.105.019901

Genes

GRK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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