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Article

A novel molecular mechanism responsible for phosphorylation-independent desensitization of G protein-coupled receptors exemplified by the dopamine D3 receptor.

Biochemical and biophysical research communications - 30 Jul 2020

Zheng Mei, Zhang Xiaohan, Sun Ningning, Min Xiao, Acharya Srijan, Kim Kyeong-Man

Abstract excerpt

GRK-mediated receptor phosphorylation followed by association with β-arrestins has been proposed to be the molecular mechanism involved in the desensitization of G protein-coupled receptors (GPCRs). However, this mechanism does not explain the desensitization of some GPCRs, such as dopamine D3 receptor (D3R), which does not undergo GRK-mediated phosphorylation. Loss-of-function approaches and mutants of dopamine...

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Identifiers

PMID: 32505358
DOI: 10.1016/j.bbrc.2020.05.197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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