Article
Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways.
The Journal of biological chemistry - 19 Sept 1997
Pals-Rylaarsdam R, Gurevich V V, Lee K B, Ptasienski J A, Benovic J L, Hosey M M
Abstract excerpt
Recent studies have identified agonist-dependent phosphorylation as a critical event in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and sequestration of the receptors away from the cell surface. However, mutant m2 mAChRs were identified that were phosphorylated but unable to desensitize in adenylyl cyclase assays, while they internalized like wild type (WT) mAChRs. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.