Article
Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D(2) receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2010
Cho Dongim, Zheng Mei, Min Chengchun, Ma Lan, Kurose Hitoshi, Park Jae H, Kim Kyeong-Man
Abstract excerpt
The regulatory mechanisms and functional roles of agonist-induced internalization of G protein-coupled receptors (GPCRs) were analyzed using mutant dopamine D(2) receptors (D(2)Rs) in which all possible GPCR kinase (GRK) phosphorylation sites were mutated or the affinity for beta-arrestins was altered. Agonist-induced internalization of D(2)Rs involved a phosphorylation-dependent component, which was mediated by...
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