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Article

G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation.

The Journal of biological chemistry - 4 Dec 2009

Namkung Yoon, Dipace Concetta, Urizar Eneko, Javitch Jonathan A, Sibley David R

Abstract excerpt

We investigated the regulatory effects of GRK2 on D(2) dopamine receptor signaling and found that this kinase inhibits both receptor expression and functional signaling in a phosphorylation-independent manner, apparently through different mechanisms. Overexpression of GRK2 was found to suppress receptor expression at the cell surface and enhance agonist-induced internalization, whereas short interfering RNA...

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Share to Cyclic AMP
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Models, Biological

Share to Phosphorylation

Share to Protein Structure, Tertiary

Share to Receptors, Dopamine D2

Share to RNA, Small Interfering

Source

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Identifiers

PMID: 19815545
DOI: 10.1074/jbc.M109.055707
PMCID: PMC2797181

Genes

GRK2

Provenance

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