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Article

Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004

Kim Sung Jae, Kim Myeong Yoon, Lee Eun Jin, Ahn Young Soo, Baik Ja-Hyun

Abstract excerpt

Two isoforms of the dopamine D2 receptor, D2L (long) and D2S (short), differ by the insertion of a 29-amino acid specific to D2L within the putative third intracellular loop of the receptor. Here, we examined D2 receptor-mediated MAPK activation in association with receptor internalization. Overexpression of beta-arrestin 1 and 2 increased the D2S-mediated activation of MAPK, whereas it did not affect the...

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Identifiers

PMID: 14684845
DOI: 10.1210/me.2003-0066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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