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Article

HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis.

Development (Cambridge, England) - 1 Sept 2004

Knosp Wendy M, Scott Virginia, Bächinger Hans Peter, Stadler H Scott

Abstract excerpt

In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of Hoxa13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in Hoxa13 mutant limbs. Biochemical analyses identified a novel series of Bmp2 and Bmp7 enhancer regions that directly interact with the HOXA13 DNA-binding domain...

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Source

Identifiers

PMID: 15342482
DOI: 10.1242/dev.01327

Genes

HOXA13
BMP2
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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