Article
HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2013
Shou Siming, Carlson Hanqian L, Perez Wilma D, Stadler H Scott
Abstract excerpt
BACKGROUND: Retinoic acid (RA), plays an essential role in the growth and patterning of vertebrate limb. While the developmental processes regulated by RA are well understood, little is known about the transcriptional mechanisms required to precisely control limb RA synthesis. Here, Aldh1a2 functions as the primary enzyme necessary for RA production which regulates forelimb outgrowth and hindlimb digit...
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