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Article

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation.

The Journal of clinical investigation - 1 Jun 2010

Villavicencio-Lorini Pablo, Kuss Pia, Friedrich Julia, Haupt Julia, Farooq Muhammed, Türkmen Seval, Duboule Denis, Hecht Jochen, Mundlos Stefan

Abstract excerpt

The molecular mechanisms that govern bone and joint formation are complex, involving an integrated network of signaling pathways and gene regulators. We investigated the role of Hox genes, which are known to specify individual segments of the skeleton, in the formation of autopod limb bones (i.e., the hands and feet) using the mouse mutant synpolydactyly homolog (spdh), which encodes a polyalanine expansion in...

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Identifiers

PMID: 20458143
DOI: 10.1172/JCI41554
PMCID: PMC2877951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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