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Article

Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2010

Perez Wilma D, Weller Crystal R, Shou Siming, Stadler H Scott

Abstract excerpt

The loss of HOXA13 function severely disrupts embryonic limb development. However, because embryos lacking HOXA13 die by mid-gestation, the defects present in the mutant limb could arise as a secondary consequence of failing embryonic health. In our analysis of the mutant Hoxa13(GFP) allele, we identified a surviving cohort of homozygous mutants exhibiting severe limb defects including: missing phalanx elements,...

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Identifiers

PMID: 20034107
DOI: 10.1002/dvdy.22183
PMCID: PMC2981150

Genes

HOXA13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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