Article
Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2010
Perez Wilma D, Weller Crystal R, Shou Siming, Stadler H Scott
Abstract excerpt
The loss of HOXA13 function severely disrupts embryonic limb development. However, because embryos lacking HOXA13 die by mid-gestation, the defects present in the mutant limb could arise as a secondary consequence of failing embryonic health. In our analysis of the mutant Hoxa13(GFP) allele, we identified a surviving cohort of homozygous mutants exhibiting severe limb defects including: missing phalanx elements,...
Topics
- Animals
- Cell Death
- Cell Proliferation
- Female
- Foot Bones
- Growth Differentiation Factor 5
- Homeodomain Proteins
- Homozygote
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- SOX9 Transcription Factor
- Skeleton