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Article

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.

Development (Cambridge, England) - 1 Dec 2004

Stickens Dominique, Behonick Danielle J, Ortega Nathalie, Heyer Babette, Hartenstein Bettina, Yu Ying, Fosang Amanda J, Schorpp-Kistner Marina, Angel Peter, Werb Zena

Abstract excerpt

The assembly and degradation of extracellular matrix (ECM) molecules are crucial processes during bone development. In this study, we show that ECM remodeling is a critical rate-limiting step in endochondral bone formation. Matrix metalloproteinase (MMP) 13 (collagenase 3) is poised to play a cru...

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Share to Bone Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chondrocytes

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Share to Matrix Metalloproteinase 9

Share to Neovascularization, Pathologic

Source

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Identifiers

PMID: 15539485
DOI: 10.1242/dev.01461
PMCID: PMC2771178

Genes

MMP13
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15539485-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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