Article
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod.
Development (Cambridge, England) - 1 Oct 1996
Fromental-Ramain C, Warot X, Messadecq N, LeMeur M, Dollé P, Chambon P
Abstract excerpt
Members of the Abdominal-B-related Hox gene subfamily (belonging to homology groups 9 to 13) are coordinately expressed during limb bud development. Only two genes from homology group 13 (Hoxa-13 and Hoxd-13) are specifically expressed in the developing distal region (the autopod), which displays the most complex and evolutionarily flexible pattern among limb 'segments'. We report here that targeted disruption of...
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