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Article

Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia.

Development (Cambridge, England) - 1 Jul 2003

Morgan Emily A, Nguyen Susan B, Scott Virginia, Stadler H Scott

Abstract excerpt

In humans and mice, mutations in Hoxa13 cause malformation of limb and genitourinary (GU) regions. In males, one of the most common GU malformations associated with loss of Hoxa13 function is hypospadia, a condition defined by the poor growth and closure of the urethra and glans penis. By examining early signaling in the developing mouse genital tubercle, we show that Hoxa13 is essential for normal expression of...

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Identifiers

PMID: 12783783
DOI: 10.1242/dev.00530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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