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Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2004

Rylander-Rudqvist Tove, Wedrén Sara, Jonasdottir Gudrun, Ahlberg Susanne, Weiderpass Elisabete, Persson Ingemar, Ingelman-Sundberg Magnus

Abstract excerpt

Estrogen unopposed by progestins is a key factor in endometrial cancer etiology. Cytochrome P450 1B1 (CYP1B1), responsible for the 4-hydroxylation of estrogen, may be important in endometrial carcinogenesis, either as a regulator of estrogen availability or as a producer of potentially genotoxic estrogen metabolites. We investigated the association of CYP1B1 genotype and endometrial cancer risk in a...

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PMID: 15342454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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