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Article

Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use.

Carcinogenesis - 1 Oct 2007

Chu William, Fyles Anthony, Sellers Edward M, McCready David R, Murphy Joan, Pal Tuya, Narod Steven A

Abstract excerpt

Tamoxifen is a selective estrogen receptor modulator that is used to treat and to prevent breast cancer; however, its use is associated with an increased risk of endometrial cancer. Tamoxifen is metabolized by various cytochrome P450 (CYP) enzymes, but predominantly by CYP3A4. In this study, we examined whether a genetic variant of the CYP3A4 gene, CYP3A4*1B, influences endometrial cancer risk--alone and when...

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Identifiers

PMID: 17434921
DOI: 10.1093/carcin/bgm087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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