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Article

HSD17B1 gene polymorphisms and risk of endometrial and breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2004

Setiawan Veronica Wendy, Hankinson Susan E, Colditz Graham A, Hunter David J, De Vivo Immaculata

Abstract excerpt

Estrogen exposure influences breast and endometrial cancer risk. The HSD17B1 gene produces an enzyme that catalyzes the conversion of estrone to estradiol. We hypothesized that genetic variations in HSD17B1 gene may alter endogenous estrogen levels and, thus, influence endometrial and breast cancer risk. We validated and genotyped polymorphisms in the HSD17B1 gene and assessed whether these single nucleotide...

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Identifiers

PMID: 14973105
DOI: 10.1158/1055-9965.epi-03-0241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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