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Article

CYP1B1 gene in endometrial cancer.

Molecular and cellular endocrinology - 28 Apr 2003

Sasaki Masahiro, Kaneuchi Masanori, Fujimoto Seiichiro, Tanaka Yuichiro, Dahiya Rajvir

Abstract excerpt

Metabolic activation of estradiol has been shown to be a key factor in endometrial carcinogenesis. 4-hydroxy estrogens (CYP1B1 metabolites) received particular attention because of their causative role in malignant transformation of various organs including endometrium. CYP1B1 displays the highest level of expression in endometrium. 4-hydroxy estrogens can bind to DNA via their quinone metabolites and cause...

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Identifiers

PMID: 12770747
DOI: 10.1016/s0303-7207(03)00079-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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