Article
Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk.
Cancer epidemiology - 1 Jun 2010
Ashton Katie A, Proietto Anthony, Otton Geoffrey, Symonds Ian, McEvoy Mark, Attia John, Gilbert Michael, Hamann Ute, Scott Rodney J
Abstract excerpt
OBJECTIVES: The incidence of endometrial cancer has recently increased substantially and studies have shown that altered levels of exogenous and endogenous hormones are associated with individual variation in endometrial cancer risk. The environmental and reproductive risk factors that influence these hormones are well known, however, genetic variants involved in hormone biosynthesis and estrogen metabolism have...
Topics
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
- Aryl Hydrocarbon Hydroxylases
- Biomarkers, Tumor
- Biosynthetic Pathways
- Endometrial Neoplasms
- Estradiol Dehydrogenases
- Estrogen Receptor alpha
- Female
- Gene Frequency
- Gonadal Steroid Hormones
- Humans
- Intracellular Signaling Peptides and Proteins